Isothermal titration calorimetry (ITC) is a technique that directly measures the exotherm or endotherm during the binding of biomolecules. Through the determination of heat, the binding constant (KB), reaction stoichiometry (n), entropy (Î”S), and enthalpy (Î”H) can be accurately obtained, and a complete set of information about molecular interactions can be provided in a single experiment . ITC is one of the classic methods for characterizing biomolecular interactions. The application scope of ITC includes: identification of interaction characteristics between small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules; enzyme kinetics; analysis of binding changes due to changes in molecular structure, etc. Globally, MicroCal instruments are commonly used in pharmaceutical manufacturers, biotechnology companies, and many universities, research institutes, and government agencies.
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